Drug interactions could improve how your drugs do the job or improve your danger for serious Unintended effects. This document isn't going to comprise all feasible drug interactions.
If you believe There have been an overdose, call your poison Command Heart or get health-related treatment straight away. Be wanting to tell or present what was taken, exactly how much, and when it transpired. How do I retail outlet and/or toss out Promethazine and Codeine?
Use warning When thinking about using Promethazine with Codeine Oral Remedy in patients 65 many years of age or more mature. Aged sufferers could possibly have greater sensitivity to codeine; larger frequency of lessened hepatic, renal, or cardiac purpose; or concomitant disorder or other drug therapy [see Warnings and Precautions ( 5.six) ]. Respiratory melancholy will be the chief threat for elderly patients treated with opioids, like Promethazine with Codeine Oral Remedy. Respiratory depression has transpired just after significant Original doses of opioids ended up administered to sufferers who were not opioid-tolerant or when opioids ended up co-administered with other agents that depress respiration [see Warnings and Precautions ( five.
The usage of Promethazine with Codeine Oral Option in people with acute or significant bronchial asthma in an unmonitored setting or in the absence of resuscitative devices is contraindicated [seeCONTRAINDICATIONS (4)]. Opioid analgesics and antitussives, including codeine, on the list of active elements in Promethazine with Codeine Oral Answer, really should not be Utilized in patients with acute febrile disease related with effective cough or in patients with Persistent respiratory sickness in which interference with capability to clear the tracheobronchial tree of secretions would've a deleterious effect on the client's respiratory function.
Therapy of overdosage is pushed by the general medical presentation, and is made up of discontinuation of Promethazine with Codeine Oral Resolution together with establishment of correct therapy. Give Major awareness to the reestablishment of enough respiratory Trade via provision of a patent and guarded airway and the establishment of assisted or controlled air flow.
Codeine Codeine and its active metabolite, morphine, are current in human milk. There are actually printed experiments and scenarios which have described excessive sedation, respiratory melancholy and Loss of life (in a single infant) in infants exposed to codeine via breast milk. Girls who're ultra-fast metabolizers of codeine reach bigger than anticipated serum levels of morphine, probably resulting in greater amounts of morphine in breast milk that could be harmful in their breastfed infants.
Promethazine hydrochloride was not mutagenic in the in vitro bacterial reverse mutation assay or clastogenic in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Take into account that this medication is prescribed mainly because your physician has judged that the advantage to you is greater than the risk of Unintended effects. Many individuals applying this medication would not have serious Negative effects.
Promethazine with Codeine Oral Answer needs to be applied with warning in patients with impairment of hepatic perform, and sufferers really should be monitored intently for respiratory depression, sedation, and hypotension.
” Increased pressure in your head (increased intracranial tension). Stay clear of using PROMETHAZINE WITH CODEINE ORAL Resolution Should you have a head harm or are already informed that you have improvements while in the tissue of one's Mind (brain lesions) or increased force as part of your head. Neuroleptic malignant syndrome (NMS) which may result in death. Show you healthcare supplier immediately When you've got any of the next indicators of NMS: higher fever
Convey to your Health care service provider about many of the medicines you're taking, which include prescription and more than-the-counter medicines, nutritional vitamins, and herbal supplements. Having PROMETHAZINE WITH CODEINE ORAL SOLUTION with specified other medicines can result in side effects or have an affect on how effectively PROMETHAZINE WITH CODEINE ORAL Option or another medicines operate. Usually do not get started or stop taking other medicines without talking to your healthcare company.
This can be associated with a lower in efficacy, and in some individuals, may perhaps result in indicators and signs of opioid withdrawal.
Existence-threatening respiratory issues (respiratory melancholy). PROMETHAZINE WITH CODEINE ORAL SOLUTION might cause breathing troubles (respiratory despair) that may transpire Anytime throughout cure and can lead to death. Your chance of respiration complications is greatest once you 1st get started having PROMETHAZINE WITH CODEINE ORAL Answer, are taking other medicines that can result in respiration troubles, have sure lung complications, are aged or have sure other health problems.
If Promethazine with Codeine Oral Option here is used for a protracted period of time in the Expecting female, suggest the individual of the risk of neonatal opioid withdrawal syndrome and make sure that suitable procedure might be readily available [see Warnings and Precautions (five.20)].